Research
Macro partitioning
High-protein diets promote long-term weight loss and prevent weight regain by increasing satiety, enhancing metabolic rate, and altering gut microbiota to favor beneficial species (Akkermansia, Bifidobacterium), while also upregulating tight junction proteins like occludin and ZO-1.
Increasing protein intake to about 18% of your daily calories can help you lose weight, keep it off, and strengthen your gut barrier. It changes your gut bacteria to be healthier and increases satiety. If you have kidney issues, talk to a doctor first.
GoodSupportsHIGH confidence
The consumption of a diet rich in proteins (18% of daily total energy as protein) resulted in 52% less weight regain compared to individuals in the control group who consumed 15% of their daily total energy as protein... proteins are pivotal in enhancing metabolic rate and modifying body composition... high-protein diet caused depletion of Prevotella spp. and enrichment in Akkermansia spp. and Bifidobacterium spp, which are associated with healthy mucosa... soybean... has been shown to enhance the expression of TJ proteins such as occludin, ZO-1, and ZO-2
Why this rating
Supported by clinical trials and animal studies showing weight loss and microbiome changes.
Source
Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues
Sara K. Al-Marzooqi et al. · Obesity Reviews · 2024
narrative_reviewCited 22×
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