Hormonal
GLP-1 receptor agonists (semaglutide, tirzepatide) induce high rates of reversion to normoglycemia in individuals with prediabetes, but these benefits are largely lost upon discontinuation of the therapy.
GLP-1 medications like semaglutide are highly effective at reversing prediabetes, with nearly all users returning to normal blood sugar levels while taking the drug. However, stopping the medication usually leads to weight regain and the return of prediabetes. Discuss with your doctor whether this is a short-term reset or a long-term management strategy for you.
discontinuation of semaglutide led to regaining two thirds of the initial weight loss and redevelopment of prediabetes... Weight regain occurred after discontinuing tirzepatide, and initial improvements in cardiometabolic risk factors—including FPG and HbA1c—also reversed with weight regain.
Why this rating
Based on randomized controlled trials (STEP 1, etc.) showing high efficacy and clear discontinuation effects.
Source
Reframing prediabetes: A call for better risk stratification and intervention
Sun H. Kim · Journal of Internal Medicine · 2024
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