Macro partitioning
Combined GIPR/GLP1R agonism lowers plasma triglyceride levels by increasing VLDL turnover (reduced hepatic VLDL-TG production and increased uptake by adipose tissue and liver).
Dual GIP/GLP-1 agonism improves lipid profiles by accelerating the clearance of triglyceride-rich lipoproteins (VLDL). This suggests that patients on these therapies may see significant improvements in triglyceride levels, which is a key risk factor for cardiovascular disease.
Combined GIPR/GLP1R agonism markedly lowered plasma triglyceride (TG) levels as explained by reduced hepatic very-low-density lipoprotein (VLDL)-TG production as well as increased TG-derived fatty acid uptake by brown and white adipose tissue which was coupled to enhanced hepatic uptake of core VLDL remnants.
Why this rating
Robust mechanistic data in mice, but pre-clinical.
Source
Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3-Leiden.CETP mice
Robin van Eenige et al. · Atherosclerosis · 2023
DOI 10.1016/j.atherosclerosis.2023.03.016
More from this paper
- Combined GIPR/GLP1R agonism significantly attenuates atherosclerosis severity (shifting lesions from severe to mild) in APOE*3-Leiden.CETP mice, an effect not achieved by single GIPR or GLP1R agonism.Moderate
- Combined GIPR/GLP1R agonism reduces systemic low-grade inflammation, evidenced by lower hepatic inflammatory markers and circulating adhesion molecules (ICAM-1, VCAM-1).Moderate
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