Research

Hormonal

Adherence to a high-carbohydrate diet (60% energy) for 14-20 weeks significantly increases regional cerebral blood flow in the nucleus accumbens (reward) and hypothalamus (homeostasis) compared to a low-carbohydrate diet (20% energy), suggesting neural mechanisms that may impede weight-loss maintenance.

If you are trying to maintain weight loss, the type of carbohydrates you eat matters for your brain's reward system. A diet high in carbohydrates (60% of calories) was shown to increase blood flow to the brain's reward and hunger centers compared to a low-carb diet (20% of calories). This neural activation may make it harder to stick to your diet long-term, even if you are eating the same number of calories. Consider reducing carbohydrate intake to lower levels to potentially dampen these reward-driven hunger signals.

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We report significant differences in rCBF in adults assigned to diets varying in carbohydrate content for several months, which appear to be partially associated with insulin secretion. These findings suggest that chronic intake of a high-carbohydrate diet may affect brain reward and homeostatic activity in ways that could impede weight-loss maintenance.
Laura M. Holsen et al. · Journal of Nutrition · 2021

Why this rating

Randomized controlled feeding trial with objective neuroimaging (pASL) and statistical correction, though subjective behavioral outcomes (hunger/cravings) did not differ.

Source

Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults

Laura M. Holsen et al. · Journal of Nutrition · 2021

DOI 10.1093/jn/nxab090

rct · n=72Cited 15×
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DOI resolved against Crossref · corpus check 2026-06-10

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