Hormonal

Discontinuation of GLP-1 based therapies leads to significant weight regain, indicating that obesity requires chronic management rather than short-term treatment.

If you stop taking GLP-1 medications like semaglutide or tirzepatide, you will likely regain the weight you lost. These drugs treat obesity as a chronic condition, meaning they are intended for long-term use to maintain weight loss.

StrongSupportsHIGH confidence

STEP 4 revealed the importance of participants remaining on semaglutide to facilitate continued weight loss and to prevent weight regain... a 1-year follow-up of participants in STEP 1 revealed marked weight regain following medication discontinuation (54).

Ariana M. Chao et al. · The Annual Review of Pharmacology and Toxicology · 2024

Why this rating

Supported by STEP 4 and STEP 1 follow-up data.

Source

Evolving Approaches for Pharmacological Therapy of Obesity

Ariana M. Chao et al. · The Annual Review of Pharmacology and Toxicology · 2024

narrative_reviewCited 15×

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