Hormonal
Semaglutide is associated with a statistically significant signal of disproportionate reporting for depressive disorders in real-world pharmacovigilance data, whereas liraglutide and tirzepatide show no such signal.
If you are taking semaglutide, be aware that real-world data shows a higher reporting rate of depression compared to other GLP-1RAs like liraglutide or tirzepatide. This does not mean the drug definitely causes depression, but it suggests you should monitor your mood, especially if you are female. Discuss any mood changes with your doctor, as they may consider drug-specific monitoring.
Only semaglutide demonstrated statistically significant SDRs for depressive disorders in both databases (FAERS: ROR 1.26... VigiBase: ROR 1.38...), while liraglutide and tirzepatide showed no SDRs.
Why this rating
Pharmacovigilance signals indicate association but do not prove causality; the paper notes insufficient evidence for causal inference.
Source
Exploring potential associations between GLP-1RAs and depressive disorders: a pharmacovigilance study based on FAERS and VigiBase data
Min Wang et al. · EClinicalMedicine · 2025
DOI 10.1016/j.eclinm.2025.103385
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