Hormonal
GLP-1 receptor agonists (GLP1RAs) and SGLT2 inhibitors should be used as first-line treatment in patients with Type 2 Diabetes and initial kidney disease, combined with Metformin.
If you have Type 2 Diabetes and early signs of kidney disease (like high blood pressure or protein in urine), ask your doctor about starting Metformin along with an SGLT2 inhibitor (like Jardiance or Farxiga). If more treatment is needed, a GLP-1 receptor agonist (like Ozempic or Trulicity) can be added. This combination is now recommended as the best way to protect your kidneys and heart.
recent American Diabetes Association (ADA)/ Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend combining Metformin with an SGLT2-i as first-line treatment in people with T2DM and initial kidney disease, with GLP1-RA being added in case of need of treatment intensification [33].
Why this rating
Based on recent ADA/KDIGO guidelines and multiple CVOTs showing renal benefits.
Source
Cardio‐renal‐metabolic disease in primary care setting
Mahmoud Ibrahim et al. · Diabetes/Metabolism Research and Reviews · 2023
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