Research
Hormonal
Semaglutide promotes significant weight loss in individuals with obesity, both with and without type 2 diabetes.
If you have obesity, ask your doctor about semaglutide. It is a once-weekly injection that has been proven to produce significant weight loss, often exceeding 15% of body weight, when combined with lifestyle changes.
StrongSupportsHIGH confidence
In STEP trials 1, 3, 4, and 8, participants without T2D achieved mean weight losses ranging from 14.9% to 17.4% from baseline to week 68 [8,58–60].
Why this rating
Based on multiple large RCTs (STEP program) with statistically significant results.
Source
Semaglutide: a key medication for managing cardiovascular-kidney-metabolic syndrome
Richard J. MacIsaac · Future Cardiology · 2025
DOI 10.1080/14796678.2025.2511412
narrative_reviewCited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide (GLP-1 receptor agonist) significantly reduces major adverse cardiovascular events (MACE) in high-risk patients with type 2 diabetes and established cardiovascular disease.Strong
- Semaglutide slows the progression of chronic kidney disease (CKD) and reduces major kidney disease events in patients with type 2 diabetes.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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