Hormonal
GLP-1 analogues (e.g., semaglutide) and dual agonists (e.g., tirzepatide) produce robust weight loss (15-21%) that approaches or exceeds bariatric surgery efficacy, with potential independent cardiovascular benefits beyond weight loss.
For patients with obesity who have not achieved sufficient weight loss with lifestyle changes alone, consider GLP-1 analogues like semaglutide (2.4 mg weekly) or dual agonists like tirzepatide. These medications can produce 15-21% weight loss, approaching the efficacy of bariatric surgery, and may offer independent cardiovascular benefits.
newer medications such as semaglutide and those in development, such as tirzepatide, produce robust weight loss efficacy that is approaching that of bariatric surgery... some therapies – such as glucagon-like-peptide-1 analogues – may promote these benefits independently of weight loss.
Why this rating
Supported by phase 3 trial data (STEP, SURMOUNT) and post-hoc analyses, though long-term CVOTs for some are still underway.
Source
Prioritizing obesity treatment: expanding the role of cardiologists to improve cardiovascular health and outcomes
Donna H. Ryan et al. · Cardiovascular Endocrinology & Metabolism · 2023
DOI 10.1097/xce.0000000000000279
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