Hormonal
Interleukin-6 (IL-6) signaling via the JAK2/STAT3 pathway acts as a critical autocrine regulator of human muscle satellite cell (SC) proliferation following acute muscle-damaging exercise.
To maximize muscle growth, you need to trigger the satellite cell response. This paper shows that muscle-damaging exercise (like eccentric contractions) spikes IL-6, which activates the JAK2/STAT3 pathway in satellite cells, driving them to proliferate. Don't fear the soreness or inflammation; it's the biological signal telling your muscle stem cells to activate and repair. Ensure you are recovering adequately to allow this proliferation to occur.
Collectively, these data illustrate that IL-6 is an important signaling molecule associated with the SC response to acute muscle-lengthening contractions in humans.
Why this rating
Small sample size (n=8), single exercise protocol, and observational/mechanistic focus rather than a functional hypertrophy outcome.
Source
Association of Interleukin-6 Signalling with the Muscle Stem Cell Response Following Muscle-Lengthening Contractions in Humans
Bryon R. McKay et al. · PLoS ONE · 2009
DOI 10.1371/journal.pone.0006027
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