Research
Hormonal
GIP signaling is necessary for nutrient-mediated inhibition of AgRP neurons, whereas GLP-1 signaling is not.
This study reveals that GIP, not just GLP-1, is essential for your brain to register that you have eaten. This explains why drugs that activate both receptors (like Mounjaro/Zepbound) may be more effective than those activating only GLP-1.
GoodSupportsHIGH confidence
GIPR blockade attenuated glucose- and Ensure-mediated AgRP neuron inhibition, but not lipid-induced AgRP neuron inhibition... pretreatment with the GLP-1R antagonist exendin 9-39 (Ex-9) had no effect on nutrient-mediated AgRP neuron inhibition
Why this rating
Robust in vivo blockade experiments using specific antibodies.
Source
Incretin hormones and pharmacomimetics rapidly inhibit AgRP neuron activity to suppress appetite
Hayley E. McMorrow et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024
DOI 10.1101/2024.03.18.585583
preprintCited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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