Hormonal
Targeting specific protein posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, and acetylation offers therapeutic potential for metabolic diseases including diabetes, obesity, and NAFLD by modulating insulin signaling, glucose metabolism, and inflammatory pathways.
This paper suggests that future treatments for metabolic diseases may target specific molecular switches (PTMs) in your cells. While you cannot directly 'dose' these switches, understanding them explains why current drugs (like SGLT-2 inhibitors or GLP-1 agonists) are effective and why lifestyle changes (diet/exercise) that influence these pathways (e.g., AMPK activation) are beneficial. Consult a doctor about emerging therapies targeting these pathways.
Leveraging PTMs of proteins provides novel insights and therapeutic targets for the prevention and treatment of metabolic disorders. Numerous drugs designed to target these modifications are currently in preclinical or clinical trials.
Why this rating
The paper is a review summarizing preclinical and some clinical data; it does not present new primary clinical trial results but synthesizes existing evidence.
Source
Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies
Yunuo Yang et al. · MedComm · 2024
DOI 10.1002/mco2.752
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