Hormonal
Acute exercise triggers the release of 'exerkines' (such as IL-6, BNP, and FGF21) from various tissues, which act as systemic signals to coordinate energy mobilization, metabolic adaptation, and cross-tissue communication.
Understand that your muscles and organs 'talk' to each other during exercise through chemical signals called exerkines. This is why exercise benefits not just the muscles working, but also your heart, brain, and metabolism. Consistent exercise ensures these beneficial signals are regularly released.
Exerkines, broadly defined, are any molecule that signals the occurrence of acute exercise to other tissues, whether that be in an autocrine, paracrine, or endocrine fashion.
Why this rating
Well-established in literature reviewed, though some specific exerkine effects in humans are still being clarified.
Source
Charting the Molecular Terrain of Exercise: Energetics, Exerkines, and the Future of Multiomic Mapping
Daniel H. Katz et al. · Physiology · 2024
DOI 10.1152/physiol.00024.2024
More from this paper
- Regular physical activity induces systemic molecular adaptations across multiple organ systems, reducing the risk of cardiovascular, metabolic, and mental health diseases through mechanisms involving energy mobilization, structural adaptation, and exerkine signaling.Strong
- Chronic exercise training leads to structural and metabolic adaptations, including mitochondrial biogenesis (via PGC-1a) and muscle hypertrophy (via mTORC), which improve energy efficiency and force generation.Strong
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