Research
Hormonal
BCAA supplementation significantly increases strength gains (specifically bench press and squat 1RM) in men undergoing resistance training, with greater magnitude than in women.
If you are a male recreational weightlifter, adding a BCAA supplement (2.5g Leucine, 1.25g Isoleucine, 1.25g Valine daily) to your 4-day/week resistance training program may help you lift more weight, particularly in the bench press and squat, compared to training without it. This benefit appears stronger in men than in women.
GoodQualifiesHIGH confidence
Strength gains were prominent, especially in men, with a 10% increase in bench press maximum observed in the BCAA group... For men, significant differences were noted in 1-RM squat... 1-RM on the bench press... and for 1-RM deadlift...
Why this rating
RCT with blinding and statistical significance.
Source
Sex-Based Effects of Branched-Chain Amino Acids on Strength Training Performance and Body Composition
Antonella Muscella et al. · Sports · 2024
DOI 10.3390/sports12100275
rct · n=100Cited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →