Adherence
Weight loss of 2.5% to 20% in individuals with obesity (with or without type 2 diabetes) is associated with statistically significant improvements in health state utilities, with the magnitude of utility gain increasing non-linearly with the percentage of weight lost.
For individuals with obesity, losing even small amounts of weight (2.5%) improves quality of life, with greater benefits as weight loss increases up to 20%. This improvement is not linear; the utility gains are significant across the board. Patients should be encouraged that weight loss positively impacts their perceived health state, though those concerned about looking 'too skinny' or losing strength should be reassured that health-focused weight management prioritizes function.
The relationship between weight change and utility change did not appear to be linear. ... Utility increases associated with various levels of weight decrease ranged from 0.011 to 0.060 in the subgroup with T2D and 0.015 to 0.077 in the subgroup without T2D.
Why this rating
Large sample size (N=405), rigorous TTO methodology, and statistically significant regression models, though it is a cross-sectional valuation study rather than a longitudinal clinical trial.
Source
Health state utilities associated with weight loss in type 2 diabetes and obesity
Kristina S. Boye et al. · Journal of Medical Economics · 2021
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