Hormonal
Semaglutide 2.4 mg administered once weekly induces significant body weight reduction (>10% in ~69% of patients) in non-diabetic adults with obesity when used as an adjunct to lifestyle programs.
For non-diabetic adults with obesity, semaglutide 2.4 mg taken once weekly, combined with lifestyle changes, can lead to an average 14.9% body weight loss over 68 weeks. This is significantly more effective than placebo. Be prepared for potential gastrointestinal side effects like nausea, which are common but often subside.
In non-diabetic individuals overweight or obese, 68 weeks of treatment with semaglutide (2.4 mg QW), decreased body weight by 14.9% relative to 2.4% in placebo treated controls (28). Impressively, 86.4% of patients treated with semaglutide showed weight loss >5% (vs. 31.5% in placebo controls), while 69.1% (vs. 12.0% in placebo controls) lost >10%...
Why this rating
Based on a large-scale clinical trial (68 weeks, n=large implied by % stats) with FDA approval.
Source
Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes
Qiming Tan et al. · Frontiers in Endocrinology · 2022
DOI 10.3389/fendo.2022.838410
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Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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