Adherence
Increasing cardiorespiratory fitness and losing body mass index (BMI) independently and synergistically slow the progression of deficit accumulation frailty (a marker of biological aging) in adults with type 2 diabetes and overweight/obesity.
If you have type 2 diabetes and are overweight, focusing on improving your aerobic fitness (like brisk walking for >175 minutes a week) and losing weight (targeting >7% loss) can significantly slow biological aging. These two actions work independently: improving fitness helps even if you don't lose much weight, and losing weight helps even if your fitness doesn't change much. Doing both provides the greatest benefit. This applies even if you are over 65.
Adults with type 2 diabetes and overweight or obesity may slow aging processes captured by a FI by increasing their cardiorespiratory fitness and losing weight.
Why this rating
Large randomized controlled trial (Look AHEAD) with 3,944 participants, though the specific analysis was exploratory.
Source
Associations that Cardiorespiratory Fitness and Body Mass Index Loss Have with Deficit Accumulation Frailty
KayLoni L. Olson et al. · Medicine & Science in Sports & Exercise · 2023
DOI 10.1249/mss.0000000000003353
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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