Hormonal
Combining Duodenal Mucosal Ablation (DMR) or Electroporation (ReCET) with GLP-1 receptor agonists (like Liraglutide or Semaglutide) can enable a majority of insulin-requiring T2D patients to eliminate exogenous insulin.
If you have Type 2 Diabetes and require insulin, ask your doctor about combining endoscopic procedures (like DMR or ReCET) with GLP-1 medications (like Semaglutide or Liraglutide). This combination has shown high success rates (up to 86% in small studies) in helping patients stop taking insulin. While it involves both a procedure and medication, the goal is to achieve insulin independence and better long-term control. This approach is still emerging, so discuss the risks and benefits with a specialist.
Previously, the same group showed that the combination of DMR and the GLP-1 agonist Liraglutide led to the elimination of exogenous insulin in >50% of patients that was maintained at 18 months... combination of ReCETTM and empirical semaglutide enabled 86% (n = 14) of patients with insulin-requiring T2D to remain off insulin at one year
Why this rating
Based on small cohort studies and abstracts; RCTs are ongoing.
Source
Metabolic Endoscopy: Should Gastroenterologists Be Treating Type 2 Diabetes?
Benjamin Norton et al. · Gastrointestinal Disorders · 2024
DOI 10.3390/gidisord6010013
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →