Hormonal
Tirzepatide treatment (5-15 mg weekly for 72 weeks) significantly improves both insulin sensitivity and beta-cell function in adults with obesity or overweight (BMI ≥27 kg/m2) with prediabetes or normoglycemia, independent of type 2 diabetes.
If you have obesity or are overweight and have prediabetes or normal blood sugar, tirzepatide (a once-weekly injection) can significantly improve how your body handles insulin and how well your pancreas functions. This happens partly because you lose weight, but also directly from the medication itself, potentially lowering your risk of developing type 2 diabetes.
Tirzepatide treatment was associated with improved insulin sensitivity (strongly related to decreased body weight and partially related to tirzepatide treatment) and β-cell function (strongly associated with tirzepatide treatment) in this population, irrespective of glycemic status.
Why this rating
Post hoc analysis of a large, randomized, double-blind, placebo-controlled trial (SURMOUNT-1).
Source
Tirzepatide Treatment and Associated Changes in β-Cell Function and Insulin Sensitivity in People With Obesity or Overweight With Prediabetes or Normoglycemia: A Post Hoc Analysis From the SURMOUNT-1 Trial
Andrea Mari et al. · Diabetes Care · 2025
DOI 10.2337/dc25-0763
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