Macro partitioning
A persistently low fat-to-energy ratio (FER) and high carbohydrate-to-energy ratio (CER) diet is not significantly associated with obesity, diabetes, cardiovascular disease, or all-cause mortality after adjusting for social environment covariates.
Maintaining a diet lower in fat and higher in carbohydrates does not appear to increase your risk of obesity, diabetes, heart disease, or death, provided you account for social factors like income and urbanization. This challenges the idea that high-carb diets are inherently unhealthy.
In contrast, the trajectory-pattern of a persistently low-FER and high-CER diet was not associated with obesity [HR 1.19 [95% CI, 0.82–1.17]], diabetes [HR 1.41 [95% CI, 0.98–2.02]], cardiovascular-disease [HR 1.48 [95% CI, 0.91–2.39]], and all-cause mortality [HR 1.23 [95% CI, 0.94–1.61]].
Why this rating
Observational study; associations became non-significant after adjusting for social environment, suggesting confounding.
Source
Twenty-Year Trajectory-Patterns of Percentage Energy From Dietary Fat vs. Carbohydrate Throughout Adult Life and Associations With Cardio-Metabolic Disease and All-Cause Mortality
Xiaoyu Guo et al. · Frontiers in Nutrition · 2021
DOI 10.3389/fnut.2021.701188
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