Hormonal
The ketone body β-hydroxybutyrate (βHB) inhibits glucose-induced GLP-1 secretion in enteroendocrine cells, with human jejunal enteroids showing sensitivity at much lower doses (10 mM) than murine cell lines (100 mM).
This research suggests that high concentrations of ketone bodies in the gut can suppress the release of GLP-1, a hormone that helps manage blood sugar and signals fullness. While this is a laboratory finding using human gut cells, it implies that metabolic states with high local ketone production (such as during fasting or specific dietary patterns) might alter how your body responds to carbohydrates by reducing this specific hormonal signal.
Results demonstrated βHB had a significant inhibitory effect on glucose-induced GLP-1 secretion at a dose of 100 mM in GLUTag cells. In differentiated human jejunal enteroid monolayers, glucose-induced secretion of GLP-1 was inhibited at a much lower dose of 10 mM βHB.
Why this rating
The study uses rigorous in vitro models including human-derived enteroids, but lacks in vivo human clinical data.
Source
βHB inhibits glucose-induced GLP-1 secretion in GLUTag and human jejunal enteroids
Erik Elebring et al. · Journal of Molecular Endocrinology · 2023
DOI 10.1530/jme-22-0115
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