Research
Hormonal
CagriSema (Cagrilintide + Semaglutide) achieves 22.7% weight loss, outperforming semaglutide alone.
CagriSema, a combination of Cagrilintide and Semaglutide, can lead to ~23% weight loss. It is more effective than Semaglutide alone.
GoodSupportsHIGH confidence
Under the “efficacy estimand”—which assumes full adherence to treatment—CagriSema led to a mean weight reduction of 22.7% after 68 weeks, compared to 11.8% with cagrilintide 2.4 mg, 16.1% with semaglutide 2.4 mg, and just 2.3% with placebo.
Why this rating
Phase 3 RCT data.
Source
Pharmacologic Disruption: How Emerging Weight Loss Therapies Are Challenging Bariatric Surgery Guidelines
Safi Alqatari et al. · Medicina · 2025
DOI 10.3390/medicina61071292
narrative_reviewCited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Tirzepatide (15mg weekly) achieves 20.9% weight loss, with 50-57% of users losing >= 20% body weight, rivaling bariatric surgery.Strong
- Emerging pharmacotherapies, specifically GLP-1 receptor agonists and multi-agonists, induce 15-25% weight loss, challenging the necessity of bariatric surgery for patients with BMI 30-40 kg/m2.Good
- Current bariatric surgery guidelines (BMI >= 35, or 30-34.9 with comorbidities) may need re-evaluation due to the efficacy of pharmacotherapy.Good
Related findings · Hormonal
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- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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