Hormonal
Dual and poly-agonists (e.g., Tirzepatide) targeting multiple receptors (GLP-1R, GIPR) provide superior weight loss compared to single-agonist GLP-1 therapies.
Dual-agonist drugs like Tirzepatide target both GLP-1 and GIP receptors, offering greater weight loss (up to 21%) than single-agonist GLP-1 drugs. This approach leverages multiple hormonal pathways for enhanced efficacy. It is a once-weekly injection suitable for those who need more potent weight loss support.
Combining multiple biological mechanisms into a single molecule has resulted in multi-receptor agonists that are more effective than the individual mono-agonists.
Why this rating
Supported by Phase 3 trial data for Tirzepatide showing higher weight loss than Semaglutide.
Source
Advancing obesity treatments through innovations in the design and manufacturing of therapeutic peptides
Søren Østergaard · Expert Opinion on Drug Discovery · 2025
DOI 10.1080/17460441.2025.2601113
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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