Research
Hormonal
Semaglutide 2.4 mg weekly produces a sustained, slowly decaying weight loss effect in adults with obesity, with an estimated 14.9% reduction in body weight over 68 weeks compared to placebo.
Take 2.4 mg of semaglutide once weekly as part of a lifestyle intervention. Expect significant weight loss (around 15% over 68 weeks) compared to placebo. Adherence is key, as discontinuation reduces effectiveness.
StrongSupportsHIGH confidence
When applied to STEP 1, they suggest a sustained, slowly decaying weight loss effect of semaglutide treatment.
Why this rating
Based on a large, randomized, double-blind, placebo-controlled trial (STEP 1) with 1961 participants.
Source
Instrumental Variable Methods to Target Hypothetical Estimands With Longitudinal Repeated Measures Data: Application to the STEP 1 Trial
Jack Bowden et al. · Statistics in Medicine · 2025
rct · n=1961Cited 4×
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