Research
Hormonal
Discontinuation of obesity pharmacotherapy leads to significant weight regain and recurrence of metabolic benefits loss, necessitating lifelong treatment or intensive lifestyle support.
Obesity is a chronic condition, much like high blood pressure. If you stop your medication, you will likely regain the weight and your health markers (like blood sugar and blood pressure) may worsen. Most people need to stay on treatment long-term to maintain their health benefits. If you want to stop, discuss a plan with your doctor, as weight regain is very common.
StrongSupportsVERY_HIGH confidence
Treatment discontinuation is associated with weight regain and recurrence of weight-related comorbidities for the majority of individuals who cease obesity-modifying medication, with a loss of the metabolic benefits achieved on pharmacotherapy...
Why this rating
Supported by STEP 4 and other trials cited.
Source
Pharmacotherapy for the management of overweight and obesity?
Patrice M. Forner et al. · Australian Journal of General Practice · 2025
narrative_reviewCited 3×
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