Adherence
In overweight or obese adults with type 2 diabetes, intensive lifestyle intervention (ILI) eliminates the association between weight variability and increased risk of major adverse cardiovascular events (MACE), whereas without ILI, high weight variability significantly increases MACE risk.
If you have type 2 diabetes and are overweight, do not avoid weight loss because you are afraid of weight fluctuations. Engage in a structured, intensive lifestyle program (diet and exercise counseling). This paper shows that the weight changes resulting from such a program do not increase your risk of heart events, unlike unmanaged weight variability.
Participants with the highest quartile of weight variability (VIM Q4) experienced a 2.23-fold higher risk of MACE compared with the lowest quartile (VIM Q1) in the DSE arm... However, there was no significant difference in the risk of MACE among the quartile groups of weight variability... in the ILI arm.
Why this rating
Post-hoc analysis of a large, multicenter randomized controlled trial (Look AHEAD) with long follow-up (median 9.6 years).
Source
Effect of intensive lifestyle intervention on the association between weight variability and major adverse cardiovascular events in overweight or obese adults with type 2 diabetes mellitus
Xiangbin Zhong et al. · Journal of Diabetes Investigation · 2023
DOI 10.1111/jdi.13964
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