Research

Macro partitioning

In older adults with low energy intake, consuming carbohydrates above 65% of total energy significantly increases the risk of physical frailty, whereas substituting carbohydrate energy with fat energy reduces this risk.

If you are an older adult who struggles to eat enough calories, avoid making carbohydrates the vast majority of your diet (over 65% of energy). Instead, ensure you are getting enough fat. Replacing some carbohydrate calories with fat calories may help reduce the risk of frailty. Focus on meeting total energy needs first, then balance macros by including adequate fats.

ModerateQualifiesMEDIUM confidence
In the subjects with low energy intake (odds ratio [OR] = 2.94, 95% confidence interval [CI] = 1.34–6.45) ... consuming carbohydrates above the acceptable macronutrient distribution range (65% of energy) was related to a higher risk of frailty. Substituting the energy from fat with carbohydrates was related to a higher risk of frailty (1%, OR = 1.05, 95% CI = 1.00–1.09; 5%, OR = 1.26, 95% CI = 1.02–1.56; 10%, OR = 1.59, 95% CI = 1.03–2.43).
Narae Yang et al. · Research Square · 2022

Why this rating

The study is a cross-sectional observational cohort, which establishes association but cannot prove causality; however, the sample size (n=954) and multivariate adjustments are robust.

Source

The Impact of High Carbohydrate Intake on Physical Frailty in Older Korean Adults: a Cohort-based Cross-sectional Study

Narae Yang et al. · Research Square · 2022

DOI 10.21203/rs.3.rs-1164783/v1

cross_sectional · n=954Cited 3×
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DOI resolved against Crossref · corpus check 2026-06-10

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