Hormonal

Habitual endurance or resistance exercise training enhances insulin-stimulated glycogen synthesis in primary human skeletal muscle stem cells compared to sedentary controls, but does not confer intrinsic protection against fatty acid-induced insulin resistance.

If you are highly active, your skeletal muscle cells are better at storing glucose as glycogen when insulin is present, regardless of whether you primarily do cardio or weight training. However, this cellular adaptation does not appear to protect your muscle cells from the negative effects of high fat exposure in a lab setting. To maximize metabolic health, maintain high activity levels, but be aware that cellular adaptations to training may not fully shield you from all metabolic insults like high lipid loads.