Hormonal
Tilorone attenuates high-fat diet-induced hepatic steatosis and improves glucose tolerance in mice by enhancing BMP9-Smad1/5/8 signaling and upregulating PPARγ expression.
This preclinical study suggests that tilorone, administered via intraperitoneal injection, can reduce liver fat and improve glucose metabolism in mice on a high-fat diet by activating specific signaling pathways. However, as this is an animal study using a synthetic small molecule administered via injection, it does not currently provide a direct, actionable protocol for human dietary or lifestyle intervention. Clinical trials are required to determine efficacy and safety in humans.
We demonstrate that tilorone attenuated HFD-induced steatosis by restoring bone morphogenetic protein 9 (BMP9)-Smad1/5/8 signaling and upregulating peroxisome proliferator-activated receptor gamma (PPARγ) expression.
Why this rating
The study uses a rigorous mouse model with multiple endpoints (PET/MRI, histology, respirometry, western blot), but it is preclinical and not a human trial.
Source
Tilorone attenuates high-fat diet-induced hepatic steatosis by enhancing BMP9-Smad1/5/8 signaling
Barnabas Horvath et al. · GeroScience · 2025
DOI 10.1007/s11357-025-01685-8
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