Research
Hormonal
Liraglutide is associated with higher rates of anxiety and medication switching compared to Tirzepatide and Semaglutide.
If you have a history of anxiety, Liraglutide might not be the best choice, as this study found it was associated with higher anxiety rates and more medication switches compared to Tirzepatide and Semaglutide. Tirzepatide may offer a better balance of efficacy and tolerability for you.
ModerateQualifiesMEDIUM confidence
Anxiety was significantly (p < 0.001) more common among the Liraglutide group (23%) when compared to Semaglutide (8.8%) and Tirzepatide (11.1%) groups. Liraglutide users were significantly more likely to switch medications (40%, p < 0.001) compared to other groups.
Why this rating
Cross-sectional survey with self-reported data; however, the statistical significance is strong.
Source
A comparison of Glucagon-like peptide-1 receptor agonists on weight change, side effects, and quality of life in Kuwait
Saad Al‐Ali et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1590379
cross_sectional · n=486Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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