Hormonal
Semaglutide 2.4 mg weekly significantly improves symptoms, functional capacity, and reduces systemic inflammation in obese patients with heart failure with preserved ejection fraction (HFpEF).
If you have heart failure with preserved ejection fraction and are obese, ask your doctor about semaglutide. It is a once-weekly injection that has been shown to significantly improve your heart failure symptoms, exercise capacity, and reduce inflammation. While it may cause temporary stomach issues, the benefits for your heart and weight are substantial.
Semaglutide significantly improves HFpEF outcomes in obese patients, with STEP HFpEF (n = 529) and STEP HFpEF DM (n = 616) demonstrating Kansas City Cardiomyopathy Questionnaire Clinical Summary Score increases of 16.6 and 13.7 points (vs. 8.7 and 6.4 with placebo, P < 0.001), weight reductions of 13.3% and 9.8% (P < 0.001), and 43.5% C-reactive protein reductions (P < 0.001), all of which are clinically relevant in HFpEF management.
Why this rating
Based on randomized controlled trials (STEP HFpEF, STEP HFpEF DM) with statistically significant primary endpoints, though limited to 52-week duration.
Source
Semaglutide in Heart Failure With Preserved Ejection Fraction: Emerging Evidence and Clinical Implications
Fnu Arty et al. · Cureus · 2025
DOI 10.7759/cureus.87605
Related findings · Hormonal
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