Research
Hormonal
Semaglutide does not significantly impact renal outcomes, including nephrolithiasis, acute kidney injury, or chronic kidney disease, in patients with overweight or obesity.
If you are using semaglutide for weight management or cardiovascular risk reduction, do not expect it to protect your kidneys. This meta-analysis found no significant impact on renal outcomes like kidney stones or acute kidney injury in overweight or obese patients.
GoodRefutesHIGH confidence
The meta-analysis revealed no significant impact of semaglutide on renal outcomes, including nephrolithiasis... acute kidney injury... chronic kidney disease
Why this rating
Meta-analysis of 10 RCTs; low heterogeneity for most renal outcomes.
Source
Effect of semaglutide on arrhythmic, major cardiovascular, and renal outcomes in patients with overweight or obesity: a systematic review and meta-analysis
Rui Wu et al. · European journal of medical research · 2025
DOI 10.1186/s40001-025-03124-y
Meta-analysis · 10 studiesCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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Related findings · Hormonal
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