Research
Macro partitioning
Orlistat (120 mg twice daily) produces a statistically significant weight reduction (>2.9% vs placebo) and improves cardiovascular risk factors in obese patients, including those with type 2 diabetes.
Orlistat is an approved option for weight loss that works by blocking fat absorption. To maximize results and minimize stomach issues, take 120mg twice daily with meals containing fat, but keep your overall fat intake moderate. You must also take vitamin supplements (A, D, E) separately from the drug to avoid deficiencies.
GoodSupportsHIGH confidence
Una metanalisi di 16 studi clinici randomizzati controllati (RCT) con placebo, che includevano oltre 10.000 pazienti, ha evidenziato che il trattamento con orlistat al dosaggio di 120 mg due volte al giorno determinava una riduzione del peso corporeo maggiore del 2,9% (95% CI: 2,5–3,4%) rispetto al gruppo di controllo. Oltre alla riduzione del peso corporeo, orlistat è risultato significativamente più efficace del placebo nel migliorare diversi fattori di rischio cardiovascolare...
Why this rating
Supported by a meta-analysis of 16 RCTs with >10,000 patients.
Source
Terapia farmacologica dell’obesità: attualità e prospettive future
Federica Vinciguerra et al. · L Endocrinologo · 2022
DOI 10.1007/s40619-022-01068-7
narrative_reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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