Hormonal
Antiobesity medications (AOMs), including both injectable GLP-1 receptor agonists and oral formulations, produce similar weight loss outcomes and safety profiles in patients with celiac disease on a gluten-free diet as they do in patients without celiac disease.
If you have celiac disease and are on a gluten-free diet, antiobesity medications (like semaglutide or liraglutide) are likely to work for you just as well as they do for people without celiac disease. You do not need to avoid these medications due to fears about gut absorption, provided your celiac disease is managed with a strict gluten-free diet.
Patients with CeD taking AOMs had similar weight loss outcomes to patients without CeD. Hence, AOMs can be a safe and effective therapy for weight management in patients with CeD.
Why this rating
Retrospective matched cohort study with a small sample size (39 CeD patients) and self-reported adherence, limiting generalizability.
Source
Efficacy of Antiobesity Medications in Patients With Celiac Disease on a Gluten-free Diet
Diego Añazco et al. · Journal of Clinical Gastroenterology · 2023
DOI 10.1097/mcg.0000000000001931
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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