Research
Hormonal
Semaglutide use in patients with pre-existing retinopathy is associated with an increased risk of retinal complications, likely due to rapid glycemic improvement, requiring cautious use.
If you have Type 2 Diabetes and existing eye disease (retinopathy), discuss the potential risk of worsening eye complications with your doctor before starting semaglutide. This risk is linked to how quickly blood sugar improves and is rare in those without pre-existing eye issues.
ModerateQualifiesMEDIUM confidence
L’aumento del rischio di complicanze retiniche (HR 1,76, p = 0,02), quasi esclusivo dei soggetti con retinopatia preesistente, e probabilmente determinato dal rapido miglioramento del compenso glicemico, suggerisce un cauto utilizzo di semaglutide in soggetti con retinopatia
Why this rating
Based on SUSTAIN 6 trial data, but the mechanism is observational/hypothesized ('probabilmente determinato').
Source
Semaglutide
Agostino Milluzzo et al. · L Endocrinologo · 2022
DOI 10.1007/s40619-022-01061-0
narrative_reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide (subcutaneous 1 mg/week and oral 14 mg/day) significantly reduces HbA1c and body weight in patients with type 2 diabetes, with subcutaneous administration showing superior efficacy compared to other GLP-1 receptor agonists.Good
- Semaglutide reduces cardiovascular risk (MACE) and improves lipid profiles and blood pressure in patients with type 2 diabetes, independent of weight loss.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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