Research
Hormonal
Tirzepatide may trigger new-onset atrial fibrillation in susceptible individuals through autonomic activation and sinoatrial node effects, despite its overall cardiometabolic benefits.
If you start tirzepatide and feel palpitations, lightheadedness, or a racing heart, seek medical attention promptly. While the drug improves long-term metabolic health, it can increase heart rate and potentially trigger atrial fibrillation in susceptible individuals. Do not ignore new cardiac symptoms.
LimitedQualifiesLOW confidence
This case describes new-onset AF in close temporal association with the initiation of tirzepatide in a woman without structural heart disease or traditional AF risk factors... GLP-1 receptor agonists, including those with dual GIP activity, consistently produce modest increases in resting heart rate, which may reflect autonomic activation and effects on the sinoatrial node.
Why this rating
Based on a single case report with a 'possible' Naranjo score; lacks controlled trial data for this specific adverse event.
Source
New-Onset Atrial Fibrillation Potentially Associated With Tirzepatide: A Case Report
Akhtar Purvez et al. · Cureus · 2025
DOI 10.7759/cureus.99651
case_report · n=1Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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