Hormonal
In patients with Type 2 Diabetes Mellitus, paracrine signaling in the adult muscle stem cell niche is activated, specifically through the upregulation of the PDGF–miR-501 pathway.
This research identifies a specific molecular pathway (PDGF-miR-501) that is overactive in the muscle stem cell niche of people with Type 2 Diabetes. This activation might contribute to muscle health issues. While this paper doesn't offer a treatment, it highlights a potential target for future therapies aimed at restoring normal signaling in the muscle niche to improve muscle health in diabetic patients.
We conclude that paracrine signaling in the adult muscle stem cell niche is activated in T2D. Skeletal muscle biopsies from patients with T2D revealed upregulation of PDGF (1.62-fold, P = .002), CLCN5-2 (2.85-fold, P = .03), and miR-501 (1.73-fold, P = .02) compared with normoglycemic controls.
Why this rating
The study uses human muscle biopsies from a controlled cohort (7 T2D vs 7 controls) with statistically significant results (P < .05) and corroborating mouse model data.
Source
Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus
Alexandra Fahrner et al. · The Journal of Clinical Endocrinology & Metabolism · 2023
DOI 10.1210/clinem/dgad041
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