Adherence
A 10-year multidomain intensive lifestyle intervention (ILI) targeting weight loss, physical activity, and diet in individuals with type 2 diabetes and obesity results in sustained long-term weight loss and lower deficit accumulation (frailty) compared to diabetes support and education (DSE), though it does not significantly improve composite cognitive function scores.
For older adults with type 2 diabetes, a structured lifestyle program focusing on diet, exercise, and regular monitoring can help maintain weight loss and reduce physical frailty over the long term, even if it doesn't necessarily improve cognitive function scores. The key is consistency and metabolic monitoring.
ILI participants had significantly lower deficit accumulation index scores... ILI participants achieved a mean weight reduction of 8.6% at year 1 and sustained relative lower weights compared with DSE participants throughout follow-up... there were no differences in composite cognitive function: 0.125 (0.024) for ILI versus 0.115 (0.023) for DSE, p = 0.78.
Why this rating
Large randomized controlled trial (N=5145) with long-term follow-up, though the current paper describes the cohort design and baseline characteristics of the follow-up phase.
Source
Rationale, design, and cohort characteristics of the Action for Health in Diabetes Aging study
Mark A. Espeland et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 2023
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