Hormonal
Semaglutide treatment in patients with chronic ankle instability (CAI) significantly improves patient-reported functional outcomes (FAAM, FAOS, CAIT) and reduces the incidence of recurrent ankle sprains and surgery, with approximately one-third of the benefit mediated by weight loss.
For patients with chronic ankle instability, especially those who are overweight or have type 2 diabetes, semaglutide may offer benefits beyond metabolic control. It is associated with improved ankle function, fewer sprains, and lower surgery rates. While weight loss contributes to this, it is not the only factor. Patients should discuss this potential orthopedic benefit with their prescribing physician, particularly if they are considering surgical intervention for ankle instability.
Semaglutide may show potential benefits as a supplementary intervention in treatment of CAI by improving patient-reported outcomes and preventing recurrent ankle sprains.
Why this rating
Observational prospective cohort study with large sample size (n=2018) but potential for residual confounding and indication bias as acknowledged by authors.
Source
Effects of semaglutide in patients with chronic ankle instability: evidence from a prospective cohort
Jieyuan Zhang et al. · Journal of Orthopaedic Surgery and Research · 2025
DOI 10.1186/s13018-025-05664-9
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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