Hormonal
Gastric greater curvature plication combined with Nissen fundoplication (GGCP + Nissen) produces significantly less long-term weight loss and inferior glucose homeostasis compared to sleeve gastrectomy (SG) in patients with obesity and type 2 diabetes models, despite being effective for GERD resolution.
If you have obesity and significant acid reflux, standard sleeve gastrectomy might worsen your reflux. A combined procedure (plication + Nissen) can fix your reflux and provide moderate weight loss, but it is less effective for weight loss and blood sugar control than standard sleeve gastrectomy. Choose based on whether reflux control or maximum weight loss is your primary goal.
GGCP + Nissen was inferior to SG both in weight loss and improvement of glucose tolerance, although GGCP + Nissen could lead a substantial weight loss and improve GERD efficiently.
Why this rating
The study is a single-center retrospective review with a small sample size (n=75) and includes an animal model, limiting generalizability compared to large-scale RCTs.
Source
Gastric greater curvature plication combined with Nissen fundoplication compared to sleeve gastrectomy in patients with obesity and animal model
Chong Cao et al. · BMC Surgery · 2025
DOI 10.1186/s12893-025-02960-3
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