Hormonal
Natural peptides (BRP, BPC-157, MOTS-c) offer a safer, more metabolically specific alternative to semaglutide for obesity management by preserving lean mass and avoiding severe gastrointestinal side effects.
Natural peptides like BRP, BPC-157, and MOTS-c are emerging as potential alternatives to semaglutide, offering weight loss with better preservation of muscle mass and fewer gastrointestinal side effects. However, current evidence is limited to animal studies. Patients should consult healthcare providers regarding the safety, dosage, and regulatory status of these peptides, as they are not yet standard FDA-approved treatments for obesity.
In obese mice, 2 weeks of BRP treatment led to a mean weight loss of 4 g, predominantly from body fat rather than muscle... In contrast, semaglutide resulted in an approximate 9 g of weight loss. This reduction was not only in fats, but also from muscle and bone loss... Natural peptides, on the other hand, provide a promising action with minimal side effects.
Why this rating
The paper cites animal studies (mice, pigs, rats) and preclinical data; no human efficacy trials are reported for the natural peptides.
Source
Natural Peptides Versus Semaglutide: A Safer Approach to Obesity Management
Muhammad Affan Abid et al. · Medicine Advances · 2025
DOI 10.1002/med4.70021
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