Hormonal
Semaglutide use for rapid weight loss causes 'semaglutide face,' characterized by facial hollowing, skin sagging, and premature aging due to subcutaneous fat loss, collagen depletion, and muscle mass reduction.
If you are using semaglutide for weight loss, be aware that rapid fat and muscle loss can cause your face to look hollow or sagged. This is a known side effect called 'semaglutide face.' You can discuss preventative or corrective measures like dermal fillers, PRP, or radiofrequency microneedling with your provider to maintain your appearance while losing weight.
One of the most prominent consequences is 'semaglutide face,' characterized by facial hollowing, loss of subcutaneous fat, skin sagging, and premature aging due to fat redistribution, collagen depletion, and muscle loss.
Why this rating
The paper is a narrative review citing observational reports and case series rather than large-scale randomized controlled trials specifically measuring facial aesthetics.
Source
Semaglutide and the skin: A brief review of dermatologic implications
Arisha Salam et al. · Cosmoderma · 2025
DOI 10.25259/csdm_97_2025
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