Adherence
Weekly injectable semaglutide demonstrates very low persistence in real-world Colombian patients, with a mean duration of use of only 93.7 days and less than 1% persistence at 12 months.
If you are starting weekly injectable semaglutide, be aware that persistence is very low in real-world settings. Most people stop within 3 months. To stay on the medication, ensure you have good access, receive proper education on how to inject, and have regular follow-up with your doctor to manage tolerability.
The mean duration of use was 93.7 ± 76.3 days, but only 13.8% and 0.2% of patients continued the treatment at 6 and 12 months of follow-up, respectively.
Why this rating
Large sample size (n=9356) and retrospective longitudinal design, though observational.
Source
Persistence of Weekly Injectable Semaglutide Use in Patients with Diabetes Mellitus and Obesity: A Retrospective Follow-Up in Colombia
Manuel Enrique Machado‐Duque et al. · Drugs - Real World Outcomes · 2025
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