Hormonal
Continuous administration of GLP-1/GIP receptor agonists (liraglutide, semaglutide, tirzepatide) produces significant weight loss (6-22%) and cardiovascular risk reduction, but discontinuation leads to rapid weight regain and loss of therapeutic benefits.
Obesity pharmacotherapy with GLP-1/GIP agonists is highly effective for weight loss and cardiovascular health, but it is not a 'cure' with a fixed end date. You must continue the medication long-term to maintain weight loss; stopping leads to rapid regain. Discuss with your doctor whether the benefits of continuous therapy outweigh the burden of daily/weekly injections and potential side effects.
Die positiven Effekte werden durch ein Absetzen der Therapie meist nivelliert. [...] Nach Abchluss der 68-wöchigen Interventionen wurde in der STEP 1-Verlängerungsstudie für insgesamt 120 Wochen ohne fortgesetzte Therapie weiter nachbeobachtet. Am Ende des Studienzeitraums waren sämtliche therapeutischen Effekte nivelliert.
Why this rating
Based on multiple high-quality, placebo-controlled, randomized trials (SCALE, STEP, SURMOUNT programs) with large sample sizes.
Source
Peptidhormonanaloga basierte medikamentöse Adipositastherapie ist effektiv
M. Azhar Hussain et al. · Die Chirurgie · 2025
DOI 10.1007/s00104-025-02402-z
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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