Hormonal
MC4R agonists significantly reduce triglyceride and LDL-C levels, and lower systolic blood pressure, but have no significant effect on fasting blood sugar, HbA1c, or diastolic blood pressure.
MC4R agonists not only help you lose weight but also significantly improve your lipid profile by lowering triglycerides and LDL cholesterol, and they can lower systolic blood pressure. However, they do not appear to have a significant effect on fasting blood sugar, HbA1c, or diastolic blood pressure. These metabolic benefits make them a valuable treatment for reducing overall cardiovascular risk in patients with obesity.
These agents reduced triglyceride levels by − 35.53 mg/dL and LDL-C levels by − 9.14 mg/dL... Systolic blood pressure declined by − 4.38 mmHg, while diastolic pressure showed no meaningful change. The effect of MC4R agonists on FBS was not statistically significant.
Why this rating
Meta-analysis of 12 clinical trials, with robust findings for lipid and blood pressure outcomes.
Source
The effect of melanocortin-4 receptor agonist drugs on obesity and metabolic risk factors: a systematic review and meta-analysis
Yanan Sun et al. · Diabetology & Metabolic Syndrome · 2025
DOI 10.1186/s13098-025-02071-2
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