Hormonal
GLP-1 receptor agonists (liraglutide, semaglutide) and dual GIP/GLP-1 agonists (tirzepatide) induce substantial weight loss (10-25%) and improve glycemic control through appetite suppression and enhanced satiety.
GLP-1 and GIP/GLP-1 agonists are highly effective for weight loss, achieving 10-25% reduction. They work by suppressing appetite and increasing satiety. Treatment requires a gradual dose increase to manage common gastrointestinal side effects like nausea. These drugs are indicated for adults with obesity or overweight with comorbidities, and should be used alongside lifestyle changes.
Agents including liraglutide and semaglutide, plus the dual glucose-dependent insulinotropic polypeptide/GLP-1 receptor agonist tirzepatide, induce substantial weight loss (approximately 10% to 25%) through appetite suppression and enhanced satiety while improving glycemic control.
Why this rating
Supported by multiple large-scale Phase 3 RCTs (SCALE, STEP, SURPASS, SURMOUNT) cited in the review.
Source
Glucagon-like peptide-1–based pharmacological treatment of obesity: a narrative review
Jang Won Son · Journal of Korean Medical Association · 2026
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