Hormonal
Semaglutide 2.4 mg significantly reduces major adverse cardiovascular events (MACE) in individuals with overweight or obesity without diabetes, establishing pharmacological weight loss as cardiovascular risk-modifying therapy.
If you have overweight or obesity but no diabetes, semaglutide 2.4 mg can help reduce your risk of serious heart problems like heart attack and stroke. This benefit is independent of your blood sugar levels. It is an injectable medication taken once a week. You should talk to your doctor about whether this is right for you, especially if you have other cardiovascular risk factors.
The SELECT trial demonstrated that semaglutide 2.4 mg significantly reduced major adverse cardiovascular events in individuals with overweight or obesity without diabetes, establishing—for the first time—that pharmacological weight loss can translate into hard cardiovascular outcome benefits independent of glycaemic control.
Why this rating
Based on a large cardiovascular outcome trial (SELECT).
Source
Modern pharmacotherapy of obesity: molecular mechanisms, clinical efficacy and future therapeutic directions
Navneeth Selvan · International Journal of Basic & Clinical Pharmacology · 2026
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