Research
Macro partitioning
Body composition-targeted agents (e.g., bimagrumab) preserve or increase lean mass while reducing fat mass, addressing the functional decline associated with rapid weight loss.
If you are concerned about losing muscle while losing weight, ask your doctor about body composition-targeted therapies. Drugs like bimagrumab are designed to burn fat while building or preserving muscle, which helps maintain strength and function.
ModerateSupportsMEDIUM confidence
The most notable is bimagrumab, an activin type II receptor antagonist that selectively reduces fat mass while increasing lean mass... In phase 2 trials, bimagrumab produced a modest, up to 6.5% weight loss, 20.5% reduction in fat mass alongside a 3.6% increase in lean mass over 48 weeks
Why this rating
Based on Phase 2 trials.
Source
Obesity pharmacotherapy reimagined: The era of multi-receptor agonists and next-generation metabolic modulators, perspectives and controversies
Ioannis Lempesis et al. · Metabolism Open · 2026
DOI 10.1016/j.metop.2026.100463
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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