Research
Hormonal
Testosterone Replacement Therapy (TRT) increases lean body mass and improves body composition in men with documented low testosterone, but no trials have evaluated its combined use with GLP-1 RAs.
If you are a man with low testosterone, TRT can help preserve muscle. However, doctors should check your levels before starting, and there is no proof yet that taking TRT alongside GLP-1s prevents muscle loss better than TRT alone.
ModerateQualifiesMEDIUM confidence
In men with confirmed low testosterone concentrations, testosterone replacement therapy (TRT) has been shown to increase lean body mass and improve selected muscle-related outcomes... To date, no randomized clinical trials have directly evaluated the combined effects of GLP-1 receptor agonist therapy and testosterone replacement on body composition outcomes.
Why this rating
Strong evidence for TRT alone; zero direct evidence for the combination.
Source
Testosterone Replacement Therapy as a Potential Strategy to Preserve Lean Mass in Men With Persistently Low Serum Testosterone Receiving GLP-1 Receptor Agonists: A Narrative Review
Luis M Canal de Velasco et al. · Cureus · 2026
DOI 10.7759/cureus.105734
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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