Research
Adherence
Discontinuation of semaglutide leads to partial weight regain, indicating that continuous treatment is necessary to maintain weight loss results.
If you stop taking semaglutide, you will likely regain some of the weight you lost. Long-term maintenance usually requires continuing the treatment.
GoodSupportsHIGH confidence
In STEP 4, the effect of stopping semaglutide treatment after 20 weeks was analyzed, showing that discontinuation of the medication results in partial weight regain, suggesting that continuous use may be necessary to maintain results.
Why this rating
Based on STEP 4 study cited in the review.
Source
Avaliação do reposicionamento farmacológico da semaglutida no processo de emagrecimento: Uma revisão da literatura
Juliano Policarpio Moura et al. · Research Society and Development · 2024
DOI 10.33448/rsd-v13i11.47305
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Semaglutide 2.4 mg administered once weekly produces significant weight loss (mean 14.9%) in adults with obesity or overweight, superior to placebo, when combined with lifestyle interventions.Good
- Semaglutide improves cardiovascular risk factors, including blood pressure and heart failure symptoms, in patients with obesity.Good
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